Proceedings of the African Diaspora Conference on Sustainable Development

The authors urge the Western donor organizations to facilitate and support the take up of such more sustainable models

On the emergent Semantic Web and overlooked issues

The emergent Semantic Web, despite being in its infancy, has already received a lotof attention from academia and industry. This resulted in an abundance of prototype systems and discussion most of which are centred around the underlying infrastructure. However, when we critically review the work done to date we realise that there is little discussion with respect to the vision of the Semantic Web. In particular, there is an observed dearth of discussion on how to deliver knowledge sharing in an environment such as the Semantic Web in effective and efficient manners. There are a lot of overlooked issues, associated with agents and trust to hidden assumptions made with respect to knowledge representation and robust reasoning in a distributed environment. These issues could potentially hinder further development if not considered at the early stages of designing Semantic Web systems. In this perspectives paper, we aim to help engineers and practitioners of the Semantic Web by raising awareness of these issues

PAPER for an Educational Digital Library

GeogDL is a digital library of geography examination resources designed to assist students in revising for a national geography examination in Singapore. As part of an iterative design process, we carried out participatory design and brainstorming with student and teacher design partners. The first study involved prospective student design partners. In response to the first study, we describe in this paper an implementation of PAPER - Personalised Adaptive Pathways for Exam Resources - a new bundle of personalized, interactive services containing a mock exam and a personal coach. The “mock exam” provides a simulation of the actual geography examination while the “personal coach” provides recommendations of exam questions tailored to suit individual ability levels. This paper concludes with findings from a second study involving teacher design partners to further refine GeogDL.Accepted versio

Современные технические средства в работе секретаря

The article examines the technical devices used in the secretary work. Guided books and magazines for secretarial business, makes recommendations for the proper selection and use of technical devices. Furthermore, in this article the author gives examples of the most popular and commonly used programs for personal computers. All of these techniques can significantly reduce the cost of working time and improve the quality of performing their job duties

Molecular correlates of response to capmatinib in advanced non-small-cell lung cancer: clinical and biomarker results from a phase I trial

Background: Dysregulation of receptor tyrosine kinase MET by various mechanisms occurs in 3%–4% of non-small-cell lung cancer (NSCLC) and is associated with unfavorable prognosis. While MET is a validated drug target in lung cancer, the best biomarker strategy for the enrichment of a susceptible patient population still remains to be defined. Towards this end we analyze here primary data from a phase I dose expansion study of the MET inhibitor capmatinib in patients with advanced MET-dysregulated NSCLC. Patients and methods: Eligible patients [≥18 years; Eastern Cooperative Oncology Group (ECOG) performance status ≤2] with MET-dysregulated advanced NSCLC, defined as either (i) MET status by immunohistochemistry (MET IHC) 2+ or 3+ or H-score ≥150, or MET/centromere ratio ≥2.0 or gene copy number (GCN) ≥5, or (ii) epidermal growth factor receptor wild-type (EGFRwt) and centrally assessed MET IHC 3+, received capmatinib at the recommended dose of 400 mg (tablets) or 600 mg (capsules) b.i.d. The primary objective was to determine safety and tolerability; the key secondary objective was to explore antitumor activity. The exploratory end point was the correlation of clinical activity with different biomarker formats. Results: Of 55 patients with advanced MET-dysregulated NSCLC, 40/55 (73%) had received two or more prior systemic therapies. All patients discontinued treatment, primarily due to disease progression (69.1%). The median treatment dur